Gerstmann Syndrome

What is Gerstmann Syndrome?

Gerstmann Syndrome is a rare neurological degenerative disorder, develops due to lesion obtained due to developmental malfunctioning or brain injury, which affects the dominant parietal lobe present at the angular gyrus.

Both children and adult can affect with this disease, but often it has identified in adults after acquired lesion obtains through brain injury. Even it has been assumed that Gerstmann Syndrome may be characteristic features of Alzheimer disease. The cerebrovascular event also can cause of Gerstmann Syndrome development. Yet now, no identified genetic component is responsible for developing the Gerstmann Syndrome and no history of inherited disorder. The childhood type of Gerstmann Syndrome may arise because of isolation with bright and intellectual mental function or brain injury 1,5.

Gerstmann Syndrome images


Main four symptoms are considered as classic features of Gerstmann Syndrome. All four symptoms arise due to a deficit of sensory abilities.

  • Affected individual unable to express thoughts in writing and clinically the condition is termed as agraphia or dysgraphia. The typical findings of agraphia or dysgraphia are unreadable and untidy writing, the irregular formation of letters, a jumble of capital and short alphabets or print and cursory writing, uneven size and shapes of alphabets and incomplete letters.
  • Unable to solve easy arithmetical calculations and clinically termed as acalculia.
  • Loss of Recognition capability of one’s own or another’s fingers and clinically termed as finger agnosia.
  • Unable to discriminate between right and left side

Gerstmann Syndrome symptoms signs diagnosis

But in very rare cases, all four symptoms appear without learning disability for the same individual. When agraphia, acalculia, agnosia and incapability of side discrimination without mental retardation is typical characteristics and referred to as “pure” Gerstmann syndrome. Usually, all four mentioned clinical characteristics are present with other deficits, But it is also possible that all four symptoms may not present at all together.

In addition, some individuals also have a problem in expressing their feeling tough speech, even they cannot properly understand other’s speech (aphasia). They may have difficulty in reading and understanding of spelling.

Children usually have developmental Gerstmann syndrome, which is recognizable after school admission. They may have poor handwriting, difficulty in understanding of simple calculations and spelling, unable to copying or tracing simple words or drawing2,3,4.


Cerebrovascular disease, like stroke or another injury to the brain, in which blood circulation become impaired into the brain is one of the major cause of developing Gerstmann Syndrome in adults. In Gerstmann syndrome, parietal lobes of the brain become affected. Therefore, symptoms are all related to lack of sensory and perception, even understanding of sensory input become impaired, as parietal lobes of the brain are responsible for these types of mechanism.

Traumatic brain injury or a brain tumor in the parietal lobes can also cause similar symptoms associated with Gerstmann syndrome. The cause of developmental Gerstmann syndrome in children is not yet understood properly. It is assumed that brain damage at the particular region of the brain can be a cause of the onset of Gerstmann syndrome1,2.


Both male and female equally have the risk of development of Gerstmann syndrome, though the incidence of this disease is very rare in general population. The disease name is derived from Dr. Josef Gerstmann, a Viennese neurologist, who first described this disorder in 19242.


Differential diagnosis is performed in Gerstmann syndrome after a symptomatic analysis found all four neurological symptoms in adults to exclude the chance of other possible underlying causes.

The primary diagnosis is based on symptomatic analysis and in the case of children it can usually possible at school going age. The symptom analysis is possible by close observation of spelling problems, unsolved simple calculation, poor handwriting, etc. Trouble in left and right side distinction can be measured by asking the affected children to show right-hand index finger and they generally fail to do, even simple drawing they cannot draw 2.


  • There is no treatment available for curing Gerstmann syndrome. Healthcare providers recommend counseling services, special education and related rehabilitation in case of developmental Gerstmann syndrome.
  • In the case of adults, neurological conditions need to treat, so that patient management can be possible. Surgical intervention may require in neurological condition to improve the condition.
  • Exceptional, symptoms of Gerstmann syndrome diminish over a period of time 1, 2,5.


Depending on the underlying cause, many symptoms may diminishing with time in adults. But in children, this outcome does not properly measure, because it has been assumed that most children possibly do not defeat their deficit, but become skilled in adjusting with their difficulties 5.


  1. Gerstmann’s Syndrome;;
  2. Gerstmann Syndrome; National Organization for Rare Diseases; Online available at
  3. Gerstmann Syndrome; WebMD; Online available at
  4. Suresh PASebastian S.; Developmental Gerstmann’s syndrome: a distinct clinical entity of learning disabilities; Pediatr Neurol. 2000 Apr;22(4):267-78.; Online available at
  5. Gerstmann Syndrome; National Institute of Neurological and Disorders and Stroke; Online available at

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