How Long Does Oxycodone Stay in Your System

What is Oxycodone?

Oxycodone is an narcotic analgesic medication. Narcotic term is used due to this medicine derive from opium. Oxycodone prescribe to reliving moderate to severe pain symptoms. The medication has addictive effect, therefore it is not prescribed for prolonged period. The prescription instruction always mentioned that when needed or SOS.(1)


Oxycodone is usually prescribed for cancer patient who have intolerable pain syndrome.


  • Oxycodone should not be prescribed for asthma patient or patient having breathing difficulty.
  • Pregnant women should not take oxycodone, as it causes breathing difficulty of the baby.
  • Oxycodone  does not recommended to any intestinal or stomach blockage patient.
  • Patient having allergic tendency avoid Oxycodone.
  • Individual having previous medical history of seizure attack, brain tumor or head injury
  • Patient has tendency to addicted by drugs or alcohol
  • Mentally ill patient
  • Urination problem
  • Renal or hepatic disease
  • Endocrinal system disorder, specifically adrenal gland disorder, including Addison’s disease or thyroid gland disorder (3)


  • Appropriately follow the prescription instruction before take the Oxycodone medication.
  • Do not crush, chew or break the medication.
  • Should not use as overdose
  • Alcohol consumption is strictly prohibited during therapy. (1,2)

Peak Levels And Half Life Of Oxycodone

The peak concentration of the oxycodone is not same for every individual; it depends upon body weight, age, previous record of drug abuse and a small extent of gender. Oral administration with a dose of 0,28mg/kg of regular release pill reached in its peak concentration after one hour. Consequently the half-life with this dose of oxycodone would be 5 hours.(1)

Oxycontin Overdosing

The oxycodone overdosing provides critical health problems, therefore it is necessary to know about how long does oxycodone stay in body system to avoid adverse events associated with overdosing of oxycodone.

The following are the symptoms of an oxycontin overdose:

  • Breathing difficulty
  • Rate of breathing become slow
  • Extreme drowsiness
  • Giddiness
  • Unconsciousness
  • Bendy or weak muscles
  • Contraction or enlargement of the pupils
  • Cold, damp skin
  • Slow heartbeat
  • skin, fingernails, lips become bluish colored
  • Coma or loss of consciousness (1,2)

side effects of oxycodone

Oxycodone Stay in the Body

how-long-does-oxycodone-stay-in-saliva-blood-urine-hair The “extended opioids” tests is performed to determine the duration of the Oxycodone can stay in the body. The detected test result usually shown that oxycodone can stay up to 4 days after oral administration. This result may vary as Oxycodone is a synthetic product and sample can vary according to the quality and quantity of the raw material. (1,2)

Oxycodone Stay in Blood

The Oxycodone concentration in the blood can detectable up to 24 hours after the drug administration. The test for Oxycodone concentration in blood assists to find the major metabolic products of Oxycodone and also to monitor the clearance of the drug from the body, abuse of the Oxycodone, to verify a opinion of Oxycodone poisoning, or to support death investigation.(1,2)

Oxycodone Stay in Hair

Hair analysis for oxycodone presence in physiological system does not provide significant result for current existence, however it has a prolonged time. But hair analysis can provide the evidence of consumption of oxycodone in the last 3 months or longer period of time. (1,2)

Oxycodone Stay in Urine

Unchanged Oxycodone and metabolic products of Oxycodone excrete through the urine and sweat. The slow metabolism can cause positive evidence of drug findings in urine sample even after 3 to 4 days.

Liver is the organ, which assists in metabolism and renal system involves excretion of  Oxycodone. Therefore, renal and liver impairment cause delayed metabolism or excretion and thus drug can accumulate in the body. (1,2)

Oxycodone Stay in Saliva Or Sweat

For quick analysis of the oxicodone present in the body can be identified by spot-check drug test. This test provides the fact of oxycodone administration history from 1 to 4 days. (1,2)


Metabolism of Oxycodone

Liver is the primary organ for Oxycodone metabolism. The major enzyme involvement is cytochrome P450, which is secreted from the liver followed by multiple metabolic pathways. the different metabolic products of oxycodone are noroxymorphone, noroxycodone and oxymorphone, which are subsequently converted into glucuronidated. (1,2)

Oxycodone Elimination From the Body

Kidney is the major excretory organ for elimination drugs, including oxycodone and small quantity is excreted via sweat. (1,2,3)

How Long Other Drugs Stay in Human Body



  1. How long does oxycodone stay in your system? (2014);Retrieve from: oxycodone-stay-in-your-system/
    Buddy T (2016); How Long Does Oxycodone Stay in Your System?; Retrieve from:
  2. Buddy T (2016); How Long Does Oxycontin Stay in Your System?; Retrieve from:

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